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Figure 2: Domain structure of CFTR. The unique R domain is essential to the regulation of the channel and needs to be phosphorylated by PKA to facilitate the gating cycle. TMD, transmembrane domain; NBD, nucleotide-binding domain; R, regulatory domain.

Figure 2: Domain structure of CFTR. The unique R domain is essential to the regulation of the channel and needs to be phosphorylated by PKA to facilitate the gating cycle. TMD, transmembrane domain; NBD, nucleotide-binding domain; R, regulatory domain.