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Figure 1 :Genomic actions are mediated through a) direct DNA binding (transactivation) or b) transcription factor inactivation (transrepression). Non-genomic actions are mediated by c) membrane-bound receptors, d) cytosolic receptors or e) interaction with cell membrane. cGR: cytosolic glucocorticoid receptor; mGR: membrane-bound glucocorticoid receptor; LBD: ligand-binding domain; DBD: DNA-binding domain; hsp 90: heat-shock protein 90; RE: response element; NFkB : nuclear factor kB; AP-1: activating protein-1. (Adopted from: Horvath, G and Wanner, A. Eur Respir J. 2006;27:172-187 with permission)

Figure 1 :Genomic actions are mediated through a) direct DNA binding (transactivation) or b) transcription factor inactivation (transrepression). Non-genomic actions are mediated by c) membrane-bound receptors, d) cytosolic receptors or e) interaction with cell membrane. cGR: cytosolic glucocorticoid receptor; mGR: membrane-bound glucocorticoid receptor; LBD: ligand-binding domain; DBD: DNA-binding domain; hsp 90: heat-shock protein 90; RE: response element; NFkB : nuclear factor kB; AP-1: activating protein-1. (Adopted from: Horvath, G and Wanner, A. Eur Respir J. 2006;27:172-187 with permission)