Annals of Thoracic Medicine
ORIGINAL ARTICLE
Year
: 2016  |  Volume : 11  |  Issue : 3  |  Page : 202--210

A systematic review on prevalence and risk factors associated with treatment- emergent central sleep apnea


Gaurav Nigam1, Charu Pathak2, Muhammad Riaz3 
1 Department of Sleep Medicine, Clay County Hospital, Flora, IL, USA
2 Department of Obstetrics and Gynecology, NSCB Medical College, Jabalpur, Madhya Pradesh, India
3 Department of Hospital Medicine, Twin Cities Community Hospital, Templeton, CA, USA

Correspondence Address:
Gaurav Nigam
Clay County Hospital, 911 Stacy Burk Drive, Flora, IL 62839
USA

Introduction: Treatment-emergent central sleep apnea (TECSA) is the appearance of central apneas and hypopneas after significant resolution of the obstructive events has been attained using positive airway pressure (PAP) therapy. The aim of the study was to determine the prevalence of TECSA and to understand what factors are associated with its development. Methods: PubMed, MEDLINE, Scopus, Web of Science and Cochran Library databases were searched with Mesh headings to locate studies linking TECSA and obstructive sleep apnea (OSA). Results: Nine studies were identified that reported the prevalence of TECSA ranging from 5.0% to 20.3%. Prevalence of TECSA for studies using only full night titration was between 5.0% and 12.1% where as it was between 6.5% and 20.3% for studies using split-night polysomnogram. The mean effective continuous PAP (CPAP) setting varied between 7.5 cm and 15.2 cm of water for patients in TECSA group and between 7.4 cm and 13.6 cm of water for the group without TECSA. Conclusions: The aggregate point prevalence of TECSA is about 8% with the estimated range varying from 5% to 20% in patients with untreated OSA. The prevalence tends to be higher for split-night studies compared to full night titration studies. TECSA can occur at any CPAP setting although extremely high CPAP settings could increase the likelihood. Male gender, higher baseline apnea-hypopnea index, and central apnea index at the time of diagnostic study could be associated with the development of TECSA at a subsequent titration study.


How to cite this article:
Nigam G, Pathak C, Riaz M. A systematic review on prevalence and risk factors associated with treatment- emergent central sleep apnea.Ann Thorac Med 2016;11:202-210


How to cite this URL:
Nigam G, Pathak C, Riaz M. A systematic review on prevalence and risk factors associated with treatment- emergent central sleep apnea. Ann Thorac Med [serial online] 2016 [cited 2021 Dec 5 ];11:202-210
Available from: https://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2016;volume=11;issue=3;spage=202;epage=210;aulast=Nigam;type=0