Annals of Thoracic Medicine
ORIGINAL ARTICLE
Year
: 2015  |  Volume : 10  |  Issue : 2  |  Page : 132--136

Determinants of functional status among survivors of severe sepsis and septic shock: One-year follow-up


Mustafa S Al Khalaf1, Fatimah H Al Ehnidi2, Hasan M Al-Dorzi3, Hani M Tamim4, Noorizan Abd-Aziz1, Balamurugan Tangiisuran1, Yahaya Hassan5, Yaseen M Arabi3 
1 Department of Clinical Pharmacist, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia
2 Research Coordinator, King Abdullah International Medical Research Centre (KAIMRC), Riyadh, Saudi Arabia
3 Department of Intensive Care, King Saud bin Abdul-Aziz University for Health Sciences, Riyadh, Saudi Arabia
4 King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
5 Department of Pharmacy Practice/Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia

Correspondence Address:
Yaseen M Arabi
Department of Intensive Care, King Abdulaziz Medical City, Associate Professor, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh
Saudi Arabia

RATIONALE: Sepsis is a leading cause of intensive care unit (ICU) admissions worldwide and a major cause of morbidity and mortality. Limited data exist regarding the outcomes and functional status among survivors of severe sepsis and septic shock. OBJECTIVES: This study aimed to determine the functional status among survivors of severe sepsis and septic shock a year after hospital discharge. METHODS: Adult patients admitted between April 2007 and March 2010 to the medical-surgical ICU of a tertiary hospital in Saudi Arabia, were included in this study. The ICU database was investigated for patients with a diagnosis of severe sepsis or septic shock. Survival status was determined based on hospital discharge. Patients who required re-admission, stayed in ICU for less than 24 hours, had incomplete data were all excluded. Survivors were interviewed through phone calls to determine their functional status one-year post-hospital discharge using Karnofsky performance status scale. RESULTS: A total of 209 patients met the eligibility criteria. We found that 38 (18.1%) patients had severe disability before admission, whereas 109 (52.2%) patients were with severe disability or died one-year post-hospital discharge. Only one-third of the survivors had good functional status one-year post-discharge (no/mild disability). After adjustment of baseline variables, age [adjusted odds ratio (aOR) = 1.03, 95% confidence interval (CI) = 1.01-1.04] and pre-sepsis functional status of severe disability (aOR = 50.9, 95% CI = 6.82-379.3) were found to be independent predictors of functional status of severe disability one-year post-hospital discharge among survivors. CONCLUSIONS: We found that only one-third of the survivors of severe sepsis and septic shock had good functional status one-year post-discharge (no/mild disability). Age and pre-sepsis severe disability were the factors that highly predicted the level of functional status one-year post-hospital discharge.


How to cite this article:
Al Khalaf MS, Al Ehnidi FH, Al-Dorzi HM, Tamim HM, Abd-Aziz N, Tangiisuran B, Hassan Y, Arabi YM. Determinants of functional status among survivors of severe sepsis and septic shock: One-year follow-up.Ann Thorac Med 2015;10:132-136


How to cite this URL:
Al Khalaf MS, Al Ehnidi FH, Al-Dorzi HM, Tamim HM, Abd-Aziz N, Tangiisuran B, Hassan Y, Arabi YM. Determinants of functional status among survivors of severe sepsis and septic shock: One-year follow-up. Ann Thorac Med [serial online] 2015 [cited 2020 Nov 26 ];10:132-136
Available from: https://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2015;volume=10;issue=2;spage=132;epage=136;aulast=Al;type=0