Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
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Year : 2017  |  Volume : 12  |  Issue : 3  |  Page : 204-208

Pulmonary consequences of hypothyroidism

1 Department of Chest, Faculty of Medicine, Assiut University Hospital, Assuit, Egypt
2 Department of Internal Medicine and Endocrinology, Assiut University Hospital, Assuit, Egypt

Correspondence Address:
Samiaa Hamdy Sadek
Assiut University Hospital, Assiut University, Assuit 71111
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/atm.ATM_364_16

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Background: Although hypothyroidism has an insidious onset and relatively asymptomatic, exertional dyspnea and fatigue can be the presenting complaints. Objectives: The aim is to assess functional lung impairment in hypothyroid patients both at rest and during exercise. Methods: A case-control study was carried out on 42 patients with newly diagnosed hypothyroidism and 12 control subjects. Hypothyroidism was diagnosed based on high value of thyroid stimulating hormone (TSH) ≥6 μIU/ml, and low value of free thyroxin (FT4) ≤0.8 ng/dl, both groups had chest X-ray, spirometry, diffusing capacity of the lungs for carbon monoxide (DLCO), arterial blood gases (ABGs) and symptom-limited exercise testing using treadmill. Results: Both groups were comparable as regard age, sex, and body mass index. Although ABG and spirometry were within normal in both groups, forced vital capacity %, and forced expiratory flow (FEF25–75) % were significantly reduced in the hypothyroid group (P = 0.014, 0.000, respectively), DLCO significantly reduced in hypothyroidism (P = 0.005). As regard exercise testing parameters, maximum oxygen consumption %, minute ventilation, tidal volume, and oxygen pulse were significantly reduced in hypothyroidism (0.005, 0.000, 0.000, and 0.02 respectively). TSH significantly negatively correlated with forced expiratory volume in 1 s %, FEF25–75%, and DLCO while they significantly positively correlated with FT4. Conclusion: Even with the presence of normal chest X-ray, arterial blood gases, and spirometry in patients with hypothyroidism DLCO and exercise testing parameters can be significantly reduced.

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