Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
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Year : 2014  |  Volume : 9  |  Issue : 4  |  Page : 209-215

Pulmonary arterial hypertension in Saudi Arabia: Patients' clinical and physiological characteristics and hemodynamic parameters. A single center experience

1 Division of Pulmonary Medicine, Department of Medicine, PSMMC, Riyadh, Saudi Arabia
2 Department of Pediatric Cardiology, Section of Congenital Heart Disease, PSCC, Riyadh, Saudi Arabia
3 High Institute of Public Health, Alexandria University, Alexandria, Egypt
4 Department of Cardiac Sciences, Section of Adult Cardiology, King Khalid University Hospital, Riyadh, Saudi Arabia
5 Saudi Association for Pulmonary Hypertension, Riyadh, Saudi Arabia

Correspondence Address:
M M Idrees
Division of Pulmonary Medicine, Prince Sultan Medical Military City, PO Box 7897 (C-110), Riyadh - 11159
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1817-1737.140127

Clinical trial registration F-3819-2011

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Aims: The main objective of this study is to describe patients' clinical characteristics and physiological and hemodynamic parameters at the time of diagnosis in a pulmonary hypertension center in Saudi Arabia. Materials and Methods: This study reports the results from a single pulmonary hypertension specialized center in Riyadh, Saudi Arabia, namely Prince Sultan Medical Military City/Cardiac Center (PSMMC & CC). Both newly diagnosed (incidence) and referred (prevalence) cases of pulmonary arterial hypertension are included. All characteristics, including clinical, physiological, and hemodynamic parameters at the time of diagnosis are described. Results: A total of 107 patients were identified as having pulmonary arterial hypertension as diagnosed by right heart catheterization. The mean age at diagnosis was 36 (± 9) years, and there was a female preponderance of 62.6%. The mean duration between symptom onset and diagnosis was 27.8 (± 9.0) months. At the time of enrollment, 56.1% of patients were in functional class III and 16.8% were in functional class IV. Fifty five patients (51.4%) were diagnosed as idiopathic pulmonary arterial hypertension, 29 patients (27.1%) as congenital heart disease associated with pulmonary arterial hypertension, 16 patients (15.0%) as connective tissue diseases associated with pulmonary arterial hypertension, 4 patients (3.7%) as heritable pulmonary arterial hypertension, and 3 patients (2.8%) as portopulmonary hypertension. Conclusion: This data highlights the current situation of pulmonary arterial hypertension in Saudi Arabia. Our patients are much younger than patients described in other international registries but still detected as late in the course of the disease. A majority of patients displays severe functional and hemodynamic compromise.

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