Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
Search Ahead of print Current Issue Archives Instructions Subscribe e-Alerts Login 
Home Email this article link Print this article Bookmark this page Decrease font size Default font size Increase font size


 
CASE REPORT
Year : 2008  |  Volume : 3  |  Issue : 4  |  Page : 146-148
Diagnosis of peripheral pulmonary carcinoid tumor using endobronchial ultrasound


1 Department of Respiratory Medicine, Royal Melbourne Hospital, Victoria 3050, Australia
2 Department of Pathology, Royal Melbourne Hospital, Victoria 3050, Australia

Date of Submission07-Feb-2008
Date of Acceptance28-Mar-2008

Correspondence Address:
Daniel P Steinfort
Department of Respiratory Medicine, Royal Melbourne Hospital, Grattan St, Victoria 3050
Australia
Login to access the Email id


DOI: 10.4103/1817-1737.43082

PMID: 19561897

Rights and Permissions

   Abstract 

A 51-year-old woman with severe asthma underwent bronchoscopy and endobronchial ultrasound (EBUS) for investigation of a 15-mm peripheral lung nodule. Histology demonstrated a typical carcinoid tumor. Pulmonary location is the second commonest site for carcinoid tumors. Diagnosis of peripheral carcinoid tumor of the lung is difficult due to its small size, poor accuracy of cytologic diagnosis, and low sensitivity of positron emission tomography in detecting it. EBUS has a high diagnostic yield and a low complication rate in the evaluation of small solitary pulmonary nodules. The ultrasound appearance of carcinoid tumors is identical to that of lung carcinomas. Prompt diagnosis of carcinoid tumor is desirable as regional lymph node metastasis is seen in 10% of patients and is associated with a reduced 5-year survival. We feel that, where possible, all patients presenting with solitary pulmonary nodules should be investigated initially using EBUS due to its high diagnostic rate and the very low incidence of adverse events.


Keywords: Pulmonary carcinoid tumor, endobronchial ultrasound, solitary pulmonary nodule


How to cite this article:
Steinfort DP, Finlay M, Irving LB. Diagnosis of peripheral pulmonary carcinoid tumor using endobronchial ultrasound. Ann Thorac Med 2008;3:146-8

How to cite this URL:
Steinfort DP, Finlay M, Irving LB. Diagnosis of peripheral pulmonary carcinoid tumor using endobronchial ultrasound. Ann Thorac Med [serial online] 2008 [cited 2020 Oct 22];3:146-8. Available from: https://www.thoracicmedicine.org/text.asp?2008/3/4/146/43082



   Case Report Top


A 51-year-old lady presented with persistently poor control of her asthma symptoms. She had a long-standing history of difficult asthma, frequently requiring oral prednisolone therapy. Respiratory function testing demonstrated moderate fixed airflow obstruction with a forced expiratory volume in 1 second (FEV 1 ) of 1.0 liter. CT scanning of the chest was performed to exclude any factors that may have been responsible for exacerbating her illness. A lobulated, well-defined, soft tissue density nodule, measuring 15 mm was identified in the left lower lobe [Figure 1] but no other abnormality was noted.

The patient underwent bronchoscopy with endobronchial examination via guide sheath (EBUS-GS). Examination in the posterobasal segment of the left lower lobe demonstrated a solid lesion [Figure 2]. Fluoroscopic examination of this region did not identify a mass. Transbronchial lung biopsy was performed via the guide sheath. The patient tolerated the procedure well and there were no complications.

Histologic examination of biopsy specimens showed soft tissue infiltrated by sheets and cords of cells with slightly irregular nuclei, intranuclear inclusions, and fine granular chromatin [Figure 3A]. Immunohistochemistry demonstrated positive staining for synaptophysin [Figure 3B] and weakly positive staining for cytokeratin, chromogranin, synaptophysin, and TTF-1. Stains for S100 demonstrated sustentacular cells around clusters of neuroendocrine cells. A diagnosis of pulmonary carcinoid tumor was made.


   Discussion Top


Carcinoid tumors are low-grade malignancies comprising neuroendocrine cells. The commonest site for such lesions is the gastrointestinal tract, with a pulmonary location being the second commonest site. [1] They are rare tumors, with population-based studies indicating an incidence of 1 to 2/100,000 in different populations. [2],[3]

The majority of pulmonary carcinoids are centrally located [4] ; when located peripherally, biopsy is difficult as the lesion is frequently small. Our case highlights the ability of EBUS to achieve diagnosis in even very small peripheral lesions. No published literature describes the diagnostic yield of conventional bronchoscopy in peripheral carcinoid tumors. Diagnosis is made more difficult as the intact bronchial mucosa overlying the carcinoid tumor prevents cells from exfoliating. The diagnostic yield of cytology in carcinoid tumors is as low as 4 [5] to 8%. [6]

EBUS has been demonstrated by numerous groups to improve the diagnostic evaluation of solitary pulmonary nodules (SPNs). Its value is most apparent with smaller lesions, [7],[8] where the yield from transbronchial biopsy falls significantly. The diagnostic yield of conventional bronchoscopy in the investigation of lesions < 2 cm is as low as 14%. [9] The use of EBUS may enable correct diagnosis in up to 70% of cases with fluoroscopically invisible SPNs [10] ; it has also been associated with a diagnostic yield of over 70% for lesions ≤ 20 mm [11] and of as much as 40% for lesions of ≤ 15 mm. [8]

Even large series examining the efficacy of EBUS report only very rare diagnosis of carcinoid tumour. Only one carcinoid was diagnosed in a cumulative 577 EBUS procedures. [10],[11],[12],[13] Carcinoid tumors comprise 1-5% of all lung malignancies, [14],[15] so these lesions are clearly underrepresented in EBUS cohorts. This significantly lower-than-expected proportion of carcinoids confirms the difficulties in bronchoscopic diagnosis of peripheral carcinoid tumors.

Without the histological diagnosis that was made possible by EBUS our patient may have gone undiagnosed for some more time. Firstly, over one-third of carcinoid tumors are diagnosed only at thoracotomy, [15] and this patient was not fit for such a procedure. Secondly, while the diagnostic accuracy of CT-guided needle biopsy is equivalent to EBUS, [16] pneumothorax rates are frequently greater than 40% [17],[18] and increase with reducing lesion size. [19] In addition, cytologic diagnosis of carcinoid is problematic, [20] complicating use of fine needle aspiration for diagnosis. Thirdly, the sensitivity of PET scanning in carcinoid tumors is low, ranging around 75%, [21] which is thought to be a result of their small size and the hypometabolic state.

While 5-year survival from typical carcinoid tumors is as much as 91%, [14] delay in diagnosis is undesirable as regional lymph node involvement is seen in 10% [15] and is associated with adverse outcomes, even in typical carcinoid tumors. [14] Distant metastases are seen in 1.5% of cases. [15]

This case illustrates the significant value of bronchoscopy using EBUS in the investigation of small peripheral pulmonary nodules. Peripheral pulmonary carcinoid tumors may reliably be diagnosed using transbronchial biopsy, and their ultrasonographic appearance seems to be similar to other bronchogenic carcinomas. We feel that, where possible, all patients presenting with solitary pulmonary nodules should be investigated initially using EBUS due to its high diagnostic rate and very low incidence of adverse events.

 
   References Top

1.Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003;97:934-59.  Back to cited text no. 1    
2.Quaedvlieg PF, Visser O, Lamers CB, Janssen-Heijen ML, Taal BG. Epidemiology and survival in patients with carcinoid disease in The Netherlands: An epidemiological study with 2391 patients. Ann Oncol 2001;12:1295-300.   Back to cited text no. 2    
3.Hemminki K, Li X. Incidence trends and risk factors of carcinoid tumors: A nationwide epidemiologic study from Sweden. Cancer 2001;92:2204-10.  Back to cited text no. 3    
4.Nessi R, Basso Ricci P, Basso Ricci S, Bosco M, Blanc M, Uslenghi C. Bronchial carcinoid tumors: Radiologic observations in 49 cases. J Thorac Imaging 1991;6:47-53.  Back to cited text no. 4    
5.Okike N, Bernatz PE, Woolner LB. Carcinoid tumors of the lung . Ann Thorac Surg 1976;22:270-7.  Back to cited text no. 5    
6.Gephardt GN, Belovich DM. Cytology of pulmonary carcinoid tumors. Acta Cytol 1982;26:434-8.   Back to cited text no. 6    
7.Paone G, Nicastri E, Lucantoni G, Dello Iacono R, Battistoni P, D'Angeli AL, et al . Endobronchial ultrasound-driven biopsy in the diagnosis of peripheral lung lesions. Chest 2005;128:3551-7.  Back to cited text no. 7    
8.Yamada N, Yamazaki K, Kurimoto N, Asahina H, Kikuchi E, Shinagawa N, et al . Factors related to diagnostic yield of transbronchial biopsy using endobronchial ultrasonography with a guide sheath in small peripheral pulmonary lesions. Chest 2007;132:603-8.  Back to cited text no. 8    
9.Baaklini WA, Reinoso MA, Gorin AB, Sharafkaneh A, Manian P. Diagnostic yield of fiberoptic bronchoscopy in evaluating solitary pulmonary nodules. Chest 2000;117:1049-54.  Back to cited text no. 9    
10.Herth FJ, Eberhardt R, Vilmann P, Krasnik M, Ernst A. Real-time endobronchial ultrasound guided transbronchial needle aspiration for sampling mediastinal lymph nodes. Thorax 2006;61:795-8.  Back to cited text no. 10    
11.Kurimoto N, Miyazawa T, Okimasa S, Maeda A, Oiwa H, Miyazu Y, et al . Endobronchial ultrasonography using a guide sheath increases the ability to diagnose peripheral pulmonary lesions endoscopically. Chest 2004;126:959-65.  Back to cited text no. 11    
12.Shirakawa T, Imamura F, Hamamoto J, Honda I, Fukushima K, Sugimoto M, et al . Usefulness of endobronchial ultrasonography for transbronchial lung biopsies of peripheral lung lesions. Respiration 2004;71:260-8.   Back to cited text no. 12    
13.Yoshikawa M, Sukoh N, Yamazaki K, Kanazawa K, Fukumoto S, Harada M, et al . Diagnostic value of endobronchial ultrasonography with a guide sheath for peripheral pulmonary lesions without X-ray fluoroscopy. Chest 2007;131:1788-93.  Back to cited text no. 13    
14.Schrevens L, Vansteenkiste J, Deneffe G, De Leyn P, Verbeken E, Vandenberghe T, et al . Clinical-radiological presentation and outcome of surgically treated pulmonary carcinoid tumors: a long-term single institution experience. Lung Cancer 2004;43:39-45.  Back to cited text no. 14    
15.Fink G, Krelbaum T, Yellin A, Bendayan D, Saute M, Glazer M, et al . Pulmonary carcinoid: Presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest 2001;119:1647-51.  Back to cited text no. 15    
16.Ohno Y, Hatabutu H, Takenaka D, Higashino T, Watanabe H, Ohbayashi C, et al . CT-guided transthoracic needle aspiration biopsy of small (< or = 20 mm) solitary pulmonary nodules . AJR Am J Roentgenol 2003;180:1665-9.   Back to cited text no. 16    
17.Kazerooni EA, Lim FT, Mikhail A, Martinez FJ. Risk of pneumothorax in CT-guided transthoracic needle aspiration biopsy of the lung. Radiology 1996;198:371-5.  Back to cited text no. 17    
18.Hirose T, Mori K, Machida S, Tominaga K, Yokoi K, Adachi M. Computed tomographic fluoroscopy-guided transthoracic needle biopsy for diagnosis of pulmonary nodules. Jpn J Clin Oncol 2000;30:259-62.  Back to cited text no. 18    
19.Cox JE, Chiles C, McManus CM, Aquino SL, Choplin RH. Transthoracic needle aspiration biopsy: Variables that affect risk of pneumothorax. Radiology 1999;212:165-8.  Back to cited text no. 19    
20.Aron M, Kapila K, Verma K. Carcinoid tumors of the lung: a diagnostic challenge in bronchial washings. Diagn Cytopathol 2004;30:62-6.  Back to cited text no. 20    
21.Daniels CE, Lowe VJ, Aubrey MC, Allen MS, Jett JR. The utility of fluorodeoxyglucose positron emission tomography in the evaluation of carcinoid tumors presenting as pulmonary nodules. Chest 2007;131:255-60.  Back to cited text no. 21    


    Figures

  [Figure 1], [Figure 2], [Figure 3A], [Figure 3B]

This article has been cited by
1 Peripheral pulmonary carcinoid tumor diagnosed by endobronchial-ultrasound-guided bronchoscopy
Ayaka Tanaka,Hiroaki Akamatsu,Hiroki Kawabata,Hiroyuki Ariyasu,Yasushi Nakamura,Nobuyuki Yamamoto
Respirology Case Reports. 2016; 4(1): 10
[Pubmed] | [DOI]
2 Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids
M. E. Caplin,E. Baudin,P. Ferolla,P. Filosso,M. Garcia-Yuste,E. Lim,K. Oberg,G. Pelosi,A. Perren,R. E. Rossi,W. D. Travis,W. D. the ENETS consensus conference participants,B. Detlief,C. Jaume,C. Frederico,C. Jaroslaw,d. H. Wouter,F. Gianfranco Delle,E. Barbro,F. Massimo,F. Diego,G. David,G. Ashley,I. Tetsuhide,J. Robert,K. Gregory,K. Fahrettin,K. Reza,K. Ulrich,K.-K. Beata,K. Eric,M. Emmanuel,N. Marianne,O. Juan,O. Dermot,P. Ulrich-Frank,P. Marianne,R. John,R. Eric,R. Guido,R. Andrea,R. Philippe,S. Ramon,S. Aldo,S. Eva,S. Anders,T. Christos,V. Marie-Pierre,W. Wolfgang,W. Bertram,Z.-P. Zeng
Annals of Oncology. 2015;
[Pubmed] | [DOI]
3 Abordaje quirúrgico del tumor carcinoide broncopulmonar
Damián Palafox,José Palafox,Laura Adriana Álvarez-Correa,Luis Emilio Flores-Cadena
Cirugía Cardiovascular. 2013;
[Pubmed] | [DOI]
4 The immune response and its therapeutic modulation in bronchiectasis
Daheshia, M. and Prahl, J.D. and Carmichael, J.J. and Parrish, J.S. and Seda, G.
Pulmonary Medicine. 2012; (280528)
[Pubmed]
5 The Immune Response and Its Therapeutic Modulation in Bronchiectasis
Massoud Daheshia,James D. Prahl,Jacob J. Carmichael,John S. Parrish,Gilbert Seda
Pulmonary Medicine. 2012; 2012: 1
[Pubmed] | [DOI]



 

Top
Print this article  Email this article
 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (121 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
    Case Report
    Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed3960    
    Printed200    
    Emailed2    
    PDF Downloaded603    
    Comments [Add]    
    Cited by others 5    

Recommend this journal