|
CASE REPORT |
|
| Year : 2008 | Volume
: 3
| Issue : 1 | Page : 23-25 |
|
| Acquired tracheoesophageal fistula due to high intracuff pressure |
|
|
Akmal A Hameed1, Hasan Mohamed1, Motasem Al-Mansoori2
1 Department of ICU, Salmaniya Medical Complex, Manama, Bahrain
2 Department of Anesthesia, Salmaniya Medical Complex, Manama, Bahrain
| Date of Submission | 15-Mar-2007 |
| Date of Acceptance | 22-Apr-2007 |
Correspondence Address:
Akmal A Hameed
Department of ICU, Salmaniya Medical Complex, P.O. Box 12, Manama
Bahrain
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1817-1737.37950
|
|
 Abstract | | |
High-compliance endotracheal tube cuffs are used to prevent gas leak and also pulmonary aspiration in mechanically ventilated patients. However, the use of the usual cuff inflation volumes may cause tracheal damage and lead to tracheoesophageal fistula.
Tracheostomy tube cuffs seal against the tracheal wall and prevent leakage of air around the tube, assuring that the tidal volume is delivered to the lungs. In the past, high-pressure cuffs were used, but these contributed to tracheal injury and have been replaced by high-volume, low-pressure cuffs. For long-term applications, some newer tubes have low-profile (tight to shaft) cuffs that facilitate the tracheostomy tube changes by eliminating the lip that forms when standard cuffs are deflated.
Keywords: Cuff leak, endotracheal tube, intracuff pressure, tracheal damage, tracheoesophageal fistula
How to cite this article:
Hameed AA, Mohamed H, Al-Mansoori M. Acquired tracheoesophageal fistula due to high intracuff pressure. Ann Thorac Med 2008;3:23-5 |
| Introduction | |  |
Tracheostomy tube cuff volumes and pressures require constant monitoring to avoid tracheal injury. Past literature recommended routine inflation and deflation of cuffs every few hours; but this has not been shown to reduce the risk of tracheal injury, and it actually increases the risk for aspiration. [1] Because cuff pressures >30 cmH 2 O compress mucosal capillaries and impair blood flow, with total occlusion occurring at 50 cmH 2 O, it is generally recommended that cuff pressures do not exceed 20 cmH 2 O. However, monitoring cuff pressure alone is insufficient, because tracheal damage and increases in cuff volume can occur even when cuff pressures are maintained within the desired range. Cuff volumes should not exceed 6 to 8 ml, ideally; and the need to inflate the cuff to >10 ml should raise concerns about tracheal injury. [2]
High-compliance endotracheal tube cuffs are used to prevent gas leak and also pulmonary aspiration in mechanically ventilated patients. However, the use of the usual cuff inflation volumes produces transmission of the pressure directly to the tracheal wall around the cuffs. When the cuff pressure is over 40 cmH 2 O, which is the perfusion pressure of the tracheal mucosa and submucosa, [3] loss of mucosal ciliar, [4],[5] ulceration, bleeding, [5] tracheal stenosis [6] and tracheoesophageal fistula [7] may occur.
| Case Report | | |
A 35-year-old male was admitted to intensive care unit through accident/emergency after a road traffic accident and having sustained multiple injuries. He was a drug addict, alcoholic, hepatitis B and C positive. He was intubated for airway protection and transferred to ICU. He had fracture 3 and 4 cervical vertebra complete transaction of spinal cord at C4 level (quadriplegic); fracture 4, 5, 6 ribs on the right side; and bilateral pneumothorax (bilateral chest tubes inserted); rupture spleen and liver.
He was taken to the operating room and spleenectomy and hepatic repair were done; and keeping in mind the seriousness of injuries and anticipating long recovery time, the elective surgical tracheostomy was done in operating room.
The patient was shifted back to the ICU on ventilator. He was started on antibiotics, and supportive care was given and the feeding was started by nasogastric tube. Multiple attempts of extubation failed; and on day 15, the assigned staff nurse noticed bubbling and air leak from the mouth and the patient started desaturating. He was febrile, with white blood cell level increasing. On suctioning through endotracheal tube, food material was noticed. Chest radiograph showed opacities in the right lower lung region and large endotracheal cuff shadow [Figure - 1]. Bronchoscopy revealed the fistula and demonstrated the passage of secretions and air. Intracuff pressure was measured and was found to be 40 cmH 2 O. Water dye was given through mouth, which was traced into the trachea. He was diagnosed as having tracheoesophageal fistula.
Appropriate antibiotic was started for aspiration pneumonia, and the patient improved with regard to his infection but later expired.
| Discussion | | |
Tracheoesophageal fistulae are severe lesions that lead to serious and often fatal pulmonary complications. These lesions are predominantly iatrogenic, occurring in the course of tracheal intubation for resuscitation; or are of malignant origin with invasion of esophageal and tracheal walls. [8]
Tracheobronchial injuries may be caused by external injuries from blunt or penetrating trauma or by internal injuries subsequent to inhalation of fumes or gases or aspiration of liquids or foreign bodies. [9] These injuries are rare but can be life threatening. Acquired, nonmalignant tracheoesophageal fistulae usually result from erosion of the tracheal and esophageal walls by endotracheal or tracheostomy tube cuffs, especially when a rigid nasogastric tube is in place. This life-threatening condition is infrequent with the use of high-volume and low-pressure cuffs.
Higher intracuff pressure is needed to maintain the cuff's sealing effect in intubated patients. Prolonged intubation and the presence of a wide-bore gastric tube cause pressure on the sandwiched mucosa between the cuff of the tracheal tube and the gastric tube. Excessive motion of the tracheal tube during frequent dressing changes and respiratory care is another predisposing factor. Local infection worsens the mucosal damage, resulting in perforation. The duration of artificial ventilation by means of a tracheal tube in these patients exerts a basic influence on the occurrence of this complication.
In our reported case, tracheoesophageal fistula occurred due to high intracuff pressure; because when high intracuff pressure was measured after noticing the TEF, it was 40 cmH 2 O.
There have been descriptions of the occurrence of tracheal sequelae, secondary to endotracheal tube cuff high pressure, since mechanical ventilation was introduced in 1950. The first endotracheal tube cuffs used were made of low-compliance latex rubber, requiring high pressure levels to seal the tracheal lumen. Since the end of the 1970s, these endotracheal tube cuffs have been replaced by ones made of high-compliance plastic. Thus, higher air volumes can be injected with only small pressure increases, decreasing the incidence of tracheal lesions. [7] Low-pressure endotracheal tube cuffs present wider support surfaces on the tracheal mucosa than do the high-pressure ones; and therefore, the pressure exerted by the former is lower.
Ischemic damage of the trachea depends on the balance between mucosal perfusion pressure and the pressure exerted by the cuff. When the cuff pressure exceeds tracheal mucosal perfusion pressure, induction of ischemia and/or necrosis will just be a question of time. [3] Tracheitis without ulceration is the initial lesion that occurs, followed by mucosal denudation and exposure of trachea cartilage. [3] Other associated factors can increase the incidence of post-intubation tracheal complications, even with cuff pressures that appear not be excessive on the tracheal mucosa. Among these factors are included the decrease in mucosal blood flow produced by hypotension, shock and anemia [4] and low oxygen delivery to tracheal tissue produced by hypoxemia, anemia and metabolic acidosis. Additional mechanical factors, such as the placement of nasogastric tubes, seem to increase the risk of developing tracheoesophageal fistulae in patients under longtime tracheal intubations. [6]
Tracheal stenosis occurs in response to tube-related trauma at various levels of the trachea, including the suprastomal area, the stoma itself, the tube cuff and the distal tip of the tube tip. The cuff site was, at one time, a common location for stenosis; but after the advent of low-pressure, high-volume cuffs for both endotracheal and tracheostomy tubes, the stoma site is now more frequently affected.
In the critical care setting, tracheal stenosis occurs in 0-16% of patients who have tracheostomies, with higher rates occurring after surgical tracheostomies are performed, as compared to percutaneous dilatational tracheostomy. The incidence in patients who require long-term ventilation is unknown because of a lack of studies performed. Patients are usually asymptomatic until the tracheal diameter is reduced to less than 5 mm, at which time they may present with dyspnea, cough, stridor and inability to clear secretions. These symptoms may not be apparent until trials with speaking valves and full capping are undertaken.
Patients who present with stridor should be evaluated for vocal cord dysfunction, tracheal stenosis and malacia and a tube that excessively blocks the trachea despite cuff deflation. Measures to prevent tracheal stenosis include the inflation of cuffs, when necessary; maintenance of intracuff pressures <20 cmH 2 O, using properly sized tracheostomy tubes; and avoidance of excessive pressure of the tube tip on either the anterior or posterior tracheal wall.
| Conclusion | | |
Endotracheal tube cuff pressures in intensive care units are routinely high and are significantly higher. Endotracheal tube cuff pressures should be routinely measured by manometer to minimize trauma to the tracheal mucosa and surrounding structures.
Many different tracheostomy tubes are available that are constructed of different materials; in different sizes, shapes and cuff design. Tubes should be selected with care, based on the patient's body habitus, ventilatory capacity and aspiration risk. Regardless of the tube chosen, every effort should be made to preserve normal speech and swallowing, as long as the patient is capable of these functions. Management of patients who have tracheostomies aims to minimize complications by avoiding overinflation of the tube cuff, even by using cuffless tubes if possible and eschewing deep suctioning. In appropriately selected patients receiving optimal management, tracheostomy ventilation can achieve long-term survival (up to several decades in patients with slowly progressive neuromuscular conditions) with an acceptable quality of life.
| References | | |
| 1. | Powaser MM, Brown MC, Chezem J, Woodburne CR, Rogenes P, Hanson B. The effectiveness of hourly cuff deflation in minimizing tracheal damage. Heart Lung 1976;5:734-41.  |
| 2. | Make BJ, Hill NS, Goldberg AI, Bach JR, Criner GJ, Dunne PE, et al. Mechanical ventilation beyond the intensive care unit: Report of a consensus conference of the American College of Chest Physicians. Chest 1998;113:289S-344S. |
| 3. | Nordin V. The trachea and cuff induced tracheal injury. Acta Otolaryngol 1977;71:7-71. |
| 4. | Klainer SA, Turndorf H, Wu WH, Maewal H, Allender P. Surface alterations due to endotracheal intubation. Am J Med 1975;58:674-83. |
| 5. | Martins RH, Braz JR, Bretan O. Lesυes early gives intubaηγo tracheal. Rev Bras Otorrinolaringol 1995;61:343-8. |
| 6. | Berlauk JF. Prolonged endotracheal intubation vs. tracheostomy. Crit Care Med 1986;14:742-6. |
| 7. | Stauffer JL, Olsen DE, Petty HT. Complications and consequences of endotracheal intubation and tracheostomy: A prospective study of 150 critically ill adult patients. Am J Med 1981;70:65-76. |
| 8. | Couraud L, Ballester MJ, Delaisement C. Acquired tracheoesophageal fistula and its management. Semin Thorac Cardiovasc Surg 1996:8:392-9. |
| 9. | Stauffer JL, Olson DE, Petty TL. Complications and consequences of endotracheal intubation and tracheotomy: A prospective study of 150 critically ill adult patients. Am J Med 1981;70:65-76. |
[Figure - 1] |
|
| This article has been cited by | | 1 |
Knowledge and practice of tracheal tube cuff pressure monitoring: a multicenter survey of anaesthesia and critical care providers in a developing country |
|
| Arinze Duke George Nwosu, Edmund Ndudi Ossai, Fidelis Anayo Onyekwulu, Adaobi Obianuju Amucheazi, Richard Ewah, Okechukwu Onwuasoigwe, Irene Akhideno | | Patient Safety in Surgery. 2022; 16(1) | | [Pubmed] | [DOI] | | | 2 |
Tracheoesophageal fistula masquerading as dysphagia and aspiration in traumatic tetraplegia |
|
| Osama Neyaz, RajKumar Yadav, Rahul Sharma, Pankaj Kandwal | | Journal of Medical Evidence. 2022; 3(1): 64 | | [Pubmed] | [DOI] | | | 3 |
Comparison of endotracheal tube cuff pressures inflated with saline or air in gynecological laparoscopic surgery |
|
| Selin SAHIN, Ahmet BESIR, Ali AKDOGAN, Ersagun TUGCUGIL, Sedat SAYLAN | | Marmara Medical Journal. 2021; | | [Pubmed] | [DOI] | | | 4 |
Prehospital Intubations Are Associated with Elevated Endotracheal Tube Cuff Pressures: A Cross-Sectional Study Characterizing ETT Cuff Pressures at a Tertiary Care Emergency Department |
|
| Ruo S. Chen, Laurel O’Connor, Matthew R. Rebesco, Kara L. LaBarge, Edgar J. Remotti, Joseph C. Tennyson | | Prehospital and Disaster Medicine. 2021; 36(3): 283 | | [Pubmed] | [DOI] | | | 5 |
Endotracheal Tube Cuff Pressure – Comparison of the Two Filling Methods – Simulated Test |
|
| Tomasz Ilczak, Michal Cwiertnia, Piotr Bialon, Michal Szlagor, Beata Kudlacik, Malgorzata Rak, Szymon Bialka, Adam Ubych, Arkadiusz Stasicki, Wioletta Waksmanska, Jan Bujok, Monika Mikulska, Rafal Bobinski, Marek Kawecki | | Prehospital and Disaster Medicine. 2021; 36(4): 421 | | [Pubmed] | [DOI] | | | 6 |
A mobile terminal application program was used for endotracheal tube cuff pressure measurement |
|
| Wei-Zhong Wang, Yao-Ying Zhou, Zhi-Juan Wang, Mei-Li Zhu, Xiao-Yan Yao, Jian-Di Yu, Yan-Hong Lin, Fei-Yun Yu, Chun-Yan Wu, Hui-Hui Zhang, Dan Lou, Yue-Hong Hu | | Journal of Clinical Monitoring and Computing. 2021; 35(3): 463 | | [Pubmed] | [DOI] | | | 7 |
High-flow tracheal oxygen: what is the current evidence? |
|
| Sa-Bi Lin, Chen-En Chiang, Chi-Wei Tseng, Wei-Lun Liu, Ke-Yun Chao | | Expert Review of Respiratory Medicine. 2020; 14(11): 1075 | | [Pubmed] | [DOI] | | | 8 |
A Fatal, Post-Intubation, Tracheoesophageal Fistula |
|
| Sher N Baig, Stefanie J Herrera, Deborah Makinde, Fuad I Abaleka, Shahnaz Akhter | | Cureus. 2020; | | [Pubmed] | [DOI] | | | 9 |
Study of tracheal cuff pressure variation in adult tracheostomized patients in the intensive care unit |
|
| Manohar Suryavanshi, Anil Kaul, Dilip Raghavan | | Journal of Marine Medical Society. 2020; 22(2): 193 | | [Pubmed] | [DOI] | | | 10 |
Efficiency of a mechanical device in controlling tracheal cuff pressure in intubated critically ill patients: a randomized controlled study |
|
| Saad Nseir,Andrey Rodriguez,Paula Saludes,Julien De Jonckheere,Jordi Valles,Antonio Artigas,Ignacio Martin-Loeches | | Annals of Intensive Care. 2015; 5(1) | | [Pubmed] | [DOI] | | | 11 |
A technique to measure the intracuff pressure continuously: anin vivodemonstration of its accuracy |
|
| Senthil G. Krishna,Archana S. Ramesh,Kris R. Jatana,Charles Elmaraghy,Meredith Merz,James Ruda,Joseph D. Tobias,Brian Anderson | | Pediatric Anesthesia. 2014; : n/a | | [Pubmed] | [DOI] | | | 12 |
Optimal care and design of the tracheal cuff in the critically ill patient |
|
| Emmanuelle Jaillette,Ignacio Martin-Loeches,Antonio Artigas,Saad Nseir | | Annals of Intensive Care. 2014; 4(1): 7 | | [Pubmed] | [DOI] | | | 13 |
Assessment of cuff presure during general anesthesia in adult patients |
|
| Ylián Ramirez,Francisca L. Tripp,Lizbeth Sandoval,Daniel A. Santana,Fiacro Jiménez | | Revista Médica Del Hospital General De México. 2014; | | [Pubmed] | [DOI] | | | 14 |
Intubation-related tracheal ischemic lesions: incidence, risk factors, and outcome |
|
| | | Intensive Care Medicine. 2013; 39(4): 575 | | [VIEW] | [DOI] | | | 15 |
Tracheoesophageal fistula treated with esophageal exclusion and cervical esophago-gastric anastomosis via a retrosternal approach |
|
| | | Chinese Medical Journal. 2013; 126(9): 1800 | | [Pubmed] | | | 16 |
Leakage of fluid around endotracheal tube cuffs: a cadaver study |
|
| Falk Birkenfeld,Ralph Lucius,Kristian Ewald | | Korean Journal of Anesthesiology. 2013; 65(5): 438 | | [Pubmed] | [DOI] | | | 17 |
Evaluation of the endotracheal tube cuff pressure resulting from four different methods of inflation in dogs |
|
| Angela Briganti,Diego A Portela,Giovanni Barsotti,Marta Romano,Gloria Breghi | | Veterinary Anaesthesia and Analgesia. 2012; 39(5): 488 | | [Pubmed] | [DOI] | | | 18 |
Cuffed pediatric endotracheal tubes |
|
| Shibasaki, M. and Nakajima, Y. and Shime, N. and Sawa, T. | | Japanese Journal of Anesthesiology. 2012; 61(9): 1023-1029 | | [Pubmed] | | | 19 |
Evaluation of the endotracheal tube cuff pressure resulting from four different methods of inflation in dogs |
|
| Briganti, A. and Portela, D.A. and Barsotti, G. and Romano, M. and Breghi, G. | | Veterinary Anaesthesia and Analgesia. 2012; 39(5): 488-494 | | [Pubmed] | | | 20 |
Prevention of VAP: Role of the artificial airway, body position and setting the ventilator |
|
| Li Bassi, G. and Ferrer, M. and Ranzani, O.T. and Marti, J-D. and Berra, L. and Fernandez, L. and Torres, A. | | European Respiratory Monograph. 2012; 55: 153-168 | | [Pubmed] | | | 21 |
Posttracheostomy tracheoesophageal fistula |
|
| Sanwal, M.K. and Ganjoo, P. and Tandon, M.S. | | Journal of Anaesthesiology Clinical Pharmacology. 2012; 28(1): 140-141 | | [Pubmed] | | | 22 |
Prediction of optimal endotracheal tube cuff volume from tracheal diameter and from patient height and age: a prospective cohort trial |
|
| Masayuki Shibasaki, Yasufumi Nakajima, Nobuaki Shime, Teiji Sawa, Daniel I. Sessler | | Journal of Anesthesia. 2012; | | [VIEW] | [DOI] | | | 23 |
Comparison of the orotracheal tube cuff pressure estimated by palpation vs. the measurement taken with a manometer [Comparación de la presión del manguito del tubo orotraqueal estimada por palpación frente a la medición tomada con un manómetro] |
|
| Muñoz, V.E. and Mojica, S. and Gómez, J.M. and Soto, R. | | Revista Ciencias de la Salud. 2011; 9(3): 17-24 | | [Pubmed] | | | 24 |
Acquired nonmalignant tracheoesophageal fistula |
|
| Abi Ghanem, M., Azar, E., Abu Khalil, B. | | Journal Medical Libanais. 2011; 59(3): 162-164 | | [Pubmed] | | | 25 |
Complex tracheal lesion: Correction with an intercostal muscle pedicle flap [Lesão complexa da traqueia: Correção com retalho pediculado de músculo intercostal] |
|
| da Costa Ferreira, H.P. and de Araújo, C.A.A. and Cavalcante, J.F. and de Melo Lima, R.P.M. | | Jornal Brasileiro de Pneumologia. 2009; 35(12): 1250-1253 | | [Pubmed] | |
|
|
|
|
|
|
|
|
|
|
|
| Article Access Statistics | | | Viewed | 13745 | | | Printed | 347 | | | Emailed | 5 | | | PDF Downloaded | 1079 | | | Comments | [Add] | | | Cited by others | 25 | | |
|
|
