Year : 2016 | Volume
: 11 | Issue : 1 | Page : 66--70
Increased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgery
Mufide Oncel1, Aysel Kiyici1, Murat Oncel2, Guven Sunam Sadi2, Emel Sahin1, Bahattin Adam1
1 Department of Biochemistry, Medical Faculty, Mevlana University, Konya, Turkey
2 Department of Thoracic Surgery, Medical Faculty, Selcuk University, Selcuklu, Konya, Turkey
Background: Videothoracoscopic surgery leads to general organ hypoperfusion by reducing mean arterial pressure, systemic vascular resistance, and end-diastolic volume index. Oxidative stress occurs as a result of hypoperfusion. Evaluation of the short-term effects of videothoracoscopic sympathectomy on serum ischemia-modified albumin (IMA), malondialdehyde (MDA), and nitric oxide (NO) levels in patients with primary hyperhidrosis was aimed.
Methods: Twenty-six patients who underwent videothoracoscopic surgery were contributed in this study. Venous blood samples were obtained from these patients 1 h before and after the surgery. IMA, MDA, and NO levels were measured in serum samples by colorimetric methods. Albumin concentrations were also measured for each sample, and albumin-adjusted IMA levels were calculated.
Results: Postoperative IMA, albumin-adjusted IMA, and MDA values were significantly higher compared to the preoperative values (P = 0.003, 0.027, 0.018, respectively). However, postoperative NO levels were lower than the preoperative values (P = 0.002). There was no significant difference between pre- and postoperative albumin concentrations, and there was no significant correlation between the parameters tested.
Conclusions: We can conclude that elevation in MDA and IMA levels after videothoracoscopic surgery was caused by increased oxidative stress due to minimal ischemia-reperfusion injury after the infusion of CO2during the surgical process. Videothoracoscopic sympathectomy operation causes a decrease in NO production, and this should be taken in consideration when evaluating nitrosative stress in videothoracoscopic surgery.
Department of Biochemistry, Medical Faculty, Mevlana University, Yeni Istanbul Cad. No: 235, 42003, Selcuklu, Konya
|How to cite this article:|
Oncel M, Kiyici A, Oncel M, Sadi GS, Sahin E, Adam B. Increased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgery.Ann Thorac Med 2016;11:66-70
|How to cite this URL:|
Oncel M, Kiyici A, Oncel M, Sadi GS, Sahin E, Adam B. Increased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgery. Ann Thorac Med [serial online] 2016 [cited 2020 Sep 18 ];11:66-70
Available from: http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2016;volume=11;issue=1;spage=66;epage=70;aulast=Oncel;type=0