Year : 2015 | Volume
: 10 | Issue : 3 | Page : 199--203
Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome
Asiye Kanbay1, Elif Kaya2, Hakan Büyükoglan2, Mehmet Güngör Kaya3, Zuhal Özer Simsek2, Nuri Tutar2, Ramazan Demir2
1 Department of Pulmonary Medicine, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey
2 Department of Pulmonary Medicine, Erciyes University, School of Medicine, Kayseri, Turkey
3 Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey
Background and Aim: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease. Recent studies showed endothelial dysfunction and pentraxin-3 both of an early marker for development of cardiovascular disease. The aim of the study was to evaluate the relationship between severity of OSAS and endothelial dysfunction and inflammatory markers including pentraxin-3 and high-sensitivity C-reactive protein (hs-CRP).
Methods: This was a cross-sectional study in which patients who had undergone a polysomnographic study for diagnosis of OSAS were recruited. Included patients were grouped according to apnea-hypopnea index (AHI) as mild (AHI between 5 and 14.9) and moderate-severe OSAS (AHI 15). Patients with AHI < 5 served as control group. Endothelial function was evaluated by flow-mediated dilatation (FMD). Serum pentraxin-3 and hs-CRP levels were measured.
Results: Eighty-three patients enrolled for the study. We found a significant increment in pentraxin-3 and hs-CRP levels and a significant decrement in FMD as the severity of OSAS increased. There was a negative correlation between FMD and AHI, pentraxin, and hs-CRP.
Conclusion: OSAS patients have significantly elevated pentraxin-3 levels and endothelial dysfunction. Furthermore, both pentraxin-3 and endothelial dysfunction were independently associated with severity of OSAS defined by AHI.
Istanbul Medeniyet University Göztepe E?itim ve Ara?t?rma Hastanesi, Gö?üs Hastaliklari Anabilim Dal?, Kad?köy, Istanbul, 03490
|How to cite this article:|
Kanbay A, Kaya E, Büyükoglan H, Kaya MG, Simsek ZÖ, Tutar N, Demir R. Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome.Ann Thorac Med 2015;10:199-203
|How to cite this URL:|
Kanbay A, Kaya E, Büyükoglan H, Kaya MG, Simsek ZÖ, Tutar N, Demir R. Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome. Ann Thorac Med [serial online] 2015 [cited 2020 Sep 23 ];10:199-203
Available from: http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2015;volume=10;issue=3;spage=199;epage=203;aulast=Kanbay;type=0