Annals of Thoracic Medicine
ORIGINAL ARTICLE
Year
: 2012  |  Volume : 7  |  Issue : 2  |  Page : 92--97

Factors associated with noninvasive ventilation response in the first day of therapy in patients with hypercapnic respiratory failure


Gul Gursel1, Muge Aydogdu1, Secil Tasyurek1, Gazi Gulbas2, Sevket Özkaya3, Sakine Nazik1, Ayse Demir1 
1 Department of Pulmonary Critical Care Medicine, Gazi University School of Medicine, Ankara, Turkey
2 Department of Pulmonary Diseases, Inönü University School of Medicine, Malatya, Turkey
3 Depatment of Pulmonary Medicine, Rize University School of Medicine, Rize, Turkey

Correspondence Address:
Muge Aydogdu
Gazi Universitesi Gögüs Hastaliklari Anabilim Dali. 11. kat. Besevler, Ankara
Turkey

Background and Aim: Noninvasive ventilation (NIV) decreases mechanical ventilation indication in the early period of acute hypercapnic respiratory failure (AHcRF) and factors for success have been studied well. But, less is known about the factors influencing the NIV response in the subacute period. This study was aimed to determine the factors influencing the reduction of PaCO 2 levels within first 24 hours of therapy. Methods: NIV response was defined as reduction of PaCO 2 level below 50 mmHg within first 24 hours. Patients with AHcRF, treated with NIV, were divided into 2 groups according to this criterion; group 1 as the nonresponsive, group 2 as the responsive. The differences in NIV methods and characteristics of the two groups were evaluated and compared in this retrospective study. Results: A total of 100 patients were included in the study; 66 of them in group 1 and 34 in group 2. No significant differences were identified between the length of NIV application and intensive care unit (ICU) stay, intubation and mortality rates, across the groups. Ninety-one percent of the patients in group 2 had received all night long NIV therapy; this was just 74% in group 1 (P=0.036). Results of multivariate analysis showed that while nocturnal application was significantly associated with better response, prior home ventilation and requirement of higher pressure support (PS) levels significantly and independently associated with poorer response to NIV therapy. Conclusion: In patients with AHcRF, all night long use of NIV may accelerate healing by improving PaCO 2 reduction within the first 24 hours. A rapid response in PaCO 2 levels should not be expected in patients requiring higher PS levels and using prior home ventilation.


How to cite this article:
Gursel G, Aydogdu M, Tasyurek S, Gulbas G, Özkaya S, Nazik S, Demir A. Factors associated with noninvasive ventilation response in the first day of therapy in patients with hypercapnic respiratory failure.Ann Thorac Med 2012;7:92-97


How to cite this URL:
Gursel G, Aydogdu M, Tasyurek S, Gulbas G, Özkaya S, Nazik S, Demir A. Factors associated with noninvasive ventilation response in the first day of therapy in patients with hypercapnic respiratory failure. Ann Thorac Med [serial online] 2012 [cited 2019 Sep 23 ];7:92-97
Available from: http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2012;volume=7;issue=2;spage=92;epage=97;aulast=Gursel;type=0