Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
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COMMENTARY
Year : 2016  |  Volume : 11  |  Issue : 2  |  Page : 112-113
PubMed-cited research articles on the Middle East respiratory syndrome


1 Department of Intensive Care, King Saud Bin Abdulaziz University, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia
2 King Abdullah International Medical Research Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia
3 Infection Control Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia

Date of Submission06-Dec-2015
Date of Acceptance12-Dec-2015
Date of Web Publication11-Apr-2016

Correspondence Address:
Yaseen Arabi
Department of Intensive Care, King Saud Bin Abdulaziz University, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh
Kingdom of Saudi Arabia
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DOI: 10.4103/1817-1737.180024

PMID: 27168858

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How to cite this article:
Arabi Y, Deeb AM, Aqeel H, Balkhy H. PubMed-cited research articles on the Middle East respiratory syndrome. Ann Thorac Med 2016;11:112-3

How to cite this URL:
Arabi Y, Deeb AM, Aqeel H, Balkhy H. PubMed-cited research articles on the Middle East respiratory syndrome. Ann Thorac Med [serial online] 2016 [cited 2020 Sep 21];11:112-3. Available from: http://www.thoracicmedicine.org/text.asp?2016/11/2/112/180024


After more than 3 years of the first reported case of the Middle East respiratory syndrome coronavirus (MERS),[1] we sought to examine the number of PubMed-cited articles on MERS from Saudi Arabia (the most affected country)[2] and other countries. We conducted a PubMed search on November 15, 2015 using the following search keywords: MERS, MERS-CoV, Human Coronavirus-Erasmus Medical Center (HCoV-EMC), Erasmus Medical Center/2012 (EMC), HCoV-EMC/2012, novel coronavirus, and human coronavirus. We classified the articles according to the affiliation of the authors: Articles from Saudi Arabia if all authors are from Saudi Arabia, collaborative articles if the authors are from different countries and at least one author from Saudi Arabia, or articles from non-Saudi Arabia. In addition, we classified the articles into the following categories: Diagnosis, epidemiology, virology/pathogenesis, treatment, prevention, review/commentary/editorial/experiences, animal models, transmission, and social (including health care providers and public). We identified a total of 634 articles on MERS [Table 1]. Of those, 70 (11%) were from Saudi Arabia, 56 (8.8%) were collaborative articles, and 508 (80.1%) from non-Saudi Arabia. The most common article categories in descending order were reviews/commentary/editorial/experiences 215 (33.9%) followed by epidemiology 119 (18.8%), MERS transmission 80 (12.6%), and virology 78 (12.3%). To date, there is no definite therapy or vaccine for MERS-CoV infection. Multiple studies were conducted to discover potential treatment, 55 (8.7%) or prevention/vaccine, 29 (4.6%) for MERS-CoV. However, there is no randomized controlled trial so far. The number of social studies, describing the knowledge, perceptions, or attitudes toward MERS or provide educational activities is very limited. These numbers contrast with what has happened with the severe acute respiratory syndrome (SARS), wherein 33 months of the onset of the outbreak, there were 2854 PubMed publications, 33 of which were clinical trials.[3] This literature search highlights the urgent need for further research on MERS, which requires high level of collaboration.
Table 1: Number and categories of PubMed-cited articles on Middle East respiratory syndrome

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   References Top

1.
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012;367:1814-20.  Back to cited text no. 1
    
2.
World Health Organization: Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Available from: . [Last cited on 2015 Nov 29].  Back to cited text no. 2
    
3.
Perl TM, Price CS. Orchestrated scientific collaboration: Critical to the control of MERS-CoV. Ann Intern Med 2015;163:313-4.  Back to cited text no. 3
    



 
 
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