Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
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ORIGINAL ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 199-203

Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome


1 Department of Pulmonary Medicine, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey
2 Department of Pulmonary Medicine, Erciyes University, School of Medicine, Kayseri, Turkey
3 Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey

Correspondence Address:
Asiye Kanbay
Istanbul Medeniyet University Göztepe E?itim ve Ara?t?rma Hastanesi, Gö?üs Hastaliklari Anabilim Dal?, Kad?köy, Istanbul, 03490
Turkey
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DOI: 10.4103/1817-1737.160840

PMID: 26229563

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Background and Aim: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease. Recent studies showed endothelial dysfunction and pentraxin-3 both of an early marker for development of cardiovascular disease. The aim of the study was to evaluate the relationship between severity of OSAS and endothelial dysfunction and inflammatory markers including pentraxin-3 and high-sensitivity C-reactive protein (hs-CRP). Methods: This was a cross-sectional study in which patients who had undergone a polysomnographic study for diagnosis of OSAS were recruited. Included patients were grouped according to apnea-hypopnea index (AHI) as mild (AHI between 5 and 14.9) and moderate-severe OSAS (AHI ΃ 15). Patients with AHI < 5 served as control group. Endothelial function was evaluated by flow-mediated dilatation (FMD). Serum pentraxin-3 and hs-CRP levels were measured. Results: Eighty-three patients enrolled for the study. We found a significant increment in pentraxin-3 and hs-CRP levels and a significant decrement in FMD as the severity of OSAS increased. There was a negative correlation between FMD and AHI, pentraxin, and hs-CRP. Conclusion: OSAS patients have significantly elevated pentraxin-3 levels and endothelial dysfunction. Furthermore, both pentraxin-3 and endothelial dysfunction were independently associated with severity of OSAS defined by AHI.


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