Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
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CASE REPORT
Year : 2014  |  Volume : 9  |  Issue : 1  |  Page : 39-41

A rare case of alpha 1-antitrypsin deficiency associated with hypogammaglobulinemia and recurrent pulmonary thrombosis


1 Department of Internal Medicine, Allergy and Immunology, St. Luke's Hospital, Chesterfield, MO, USA
2 Department of Pulmonology, Allergy and Immunology, St. Luke's Hospital, Chesterfield, MO, USA

Correspondence Address:
Raghav Gupta
14463, Greencastle Drive, Apt#6, Chesterfield, MO 63017
USA
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DOI: 10.4103/1817-1737.124442

PMID: 24551017

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Alpha 1-antitrypsin (AAT) belongs to the family of serpins (serine protease inhibitors). Loop sheet polymerization is the pathology behind serpinopathies which encompasses AAT, anti-thrombin III and neuroserpin deficiency. To the best of our knowledge, we report the first case of alpha 1-antitrypsin deficiency associated with hypogammaglobulinemia and recurrent pulmonary thrombosis without any concomitant use of drugs.


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