Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
Search Ahead of print Current Issue Archives Instructions Subscribe e-Alerts Login 
Home Email this article link Print this article Bookmark this page Decrease font size Default font size Increase font size
REVIEW ARTICLE
Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 71-77

Approach to acute exacerbation of idiopathic pulmonary fibrosis


Department of Pulmonary and Critical Care, UF College of Medicine at, Jacksonville, Florida, USA

Correspondence Address:
Ankur Girdhar
Department of Pulmonary and Critical Care, UF College of Medicine at Jacksonville, 655 West, 8th Street, Jacksonville, Florida 32209
USA
Login to access the Email id


DOI: 10.4103/1817-1737.109815

PMID: 23741267

Rights and Permissions

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia with a median survival of 3 years after diagnosis. Acute exacerbation of IPF (AE-IPF) is now identified as a life-threatening complication. It presents as worsening dyspnea with new ground glass opacities superimposed upon a radiographic usual interstitial pneumonia (UIP) pattern. It is a diagnosis of exclusion. The prognosis of AE-IPF is poor and treatment strategies lack standardization. In order to rule out any reversible etiology for an acute decompensation of a previously stable IPF patient diagnostic modalities include computerized tomographic angiogram (CTA) coupled with high-resolution computerized tomography (HRCT) imaging of the chest, bronchoalveolar lavage (BAL) and echocardiogram with bubble study. Avoiding risk factors, identifying underlying causes and supportive care are the mainstays of treatment. Anti-inflammatory and immunosuppressant medications have not shown to improve survival in AE-IPF. Most of the patients are managed in a critical care setting with mechanical ventilation. Lung transplantation is a promising option but most institutions are not equipped and not every patient is a candidate.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed19805    
    Printed202    
    Emailed5    
    PDF Downloaded1666    
    Comments [Add]    
    Cited by others 2    

Recommend this journal