Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
Search Ahead of print Current Issue Archives Instructions Subscribe e-Alerts Login 
Home Email this article link Print this article Bookmark this page Decrease font size Default font size Increase font size
ORIGINAL ARTICLE
Year : 2013  |  Volume : 8  |  Issue : 1  |  Page : 46-52

The effectiveness of heliox in acute respiratory distress syndrome


1 Department of Pediatric Hematology and Oncology, Ondokuz Mayis University, Faculty of Medicine, Samsun/Atakum, Turkey
2 Experimental Research and Practice Center of Medical, Cukurova University, Faculty of Medicine, Adana, Turkey
3 Pediatric Intensive Care Unit, Cukurova University, Faculty of Medicine, Adana, Turkey
4 Department of Pediatric Hematology and Oncology, Cukurova University, Faculty of Medicine, Adana, Turkey
5 Department of Pathology, Cukurova University, Faculty of Medicine, Adana, Turkey
6 Department of Histology, Cukurova University, Faculty of Medicine, Adana, Turkey

Correspondence Address:
Sema Yilmaz
Department of Pediatric Hematology and Oncology, Ondokuz Mayis University, Faculty of Medicine, Samsun
Turkey
Login to access the Email id


DOI: 10.4103/1817-1737.105719

PMID: 23440627

Rights and Permissions

Introduction: The management of acute respiratory distress syndrome (ARDS) was investigated with the use of heliox in an experimental model. Objectives: To investigate whether heliox can be considered a new therapeutic approach in ARDS. Methods: ARDS was designed in Wistar albino male rats, 250-300 g in weight, by intratracheal instillation of physiological saline solution. Anesthezied and tracheotomized rats with ARDS were pressure-controlled ventilated. At the end of 210 min, helium gas was tried. All rats were assigned to two groups: Group 1 ( n = 10) was the control group, and was given no treatment; group 2 ( n = 7) was given heliox (He: O 2 = 50:50). The heliox group received heliox for 1 h continously. Rats were continued to be kept on a ventilator through the experiment. Two hours after the last inhalation, both lungs of the rats were excised for both histopathological examination and immunohistochemical evaluation. Statistical Analysis Used: Histopathological grading were expressed as median interquartile range. Mann-Whitney U-test was used to assess the relationships between the variables. Results: The infiltation of neutrophils were decreased in rats treated with heliox. Edema in the interstitial and intraalveolar areas was less than that of the control rats. Also, the diminishing of perivascular and/or intraalveolar hemorrhage was apperant. Hyaline membrane (HM) formation decreased in the heliox group compared with the control group. Decreased inducible nitric oxide synthase expression was shown via immunohistochemical examination in the heliox group. Conclusion: The present study histopathologically indicated the effectiveness of heliox in the decreasing of neutrophil infiltation, interstitial/intraalveolar edema, perivascular and/or intraalveolar hemorrhage and HM formation in ARDS. Besides the known effect of heliox in obstructive lung disease, inhaled heliox therapy could be associated with the improvement of inflamation in ARDS.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5423    
    Printed145    
    Emailed3    
    PDF Downloaded596    
    Comments [Add]    
    Cited by others 6    

Recommend this journal