Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
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ORIGINAL ARTICLE
Year : 2012  |  Volume : 7  |  Issue : 1  |  Page : 16-20

Study of the association between −403G/A and −28C/G RANTES gene polymorphisms and asthma in Lebanon


1 Department of Pharmacology, Faculty of Pharmacy, Beirut Arab University, Riyadh, Saudi Arabia
2 Department of Basic Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
3 Department of Biological and Environmental Sciences, Faculty of Science, Beirut Arab University, Riyadh, Saudi Arabia

Correspondence Address:
Hana M Fakhoury
Department of Basic Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, P. O. Box 22490 Riyadh 11426
Saudi Arabia
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DOI: 10.4103/1817-1737.91558

PMID: 22347345

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Context: Asthma is a complex inflammatory condition often associated with bronchial hyper reactivity and atopy. Genetic and environmental factors are implicated in the etiopathogenesis of asthma. Regulated upon Activation Normal T- cell Expressed and Secreted (RANTES) is a CC chemokine responsible for the recruitment of inflammatory cells, suggesting a possible role for this chemokine in asthma. Both -403A and -28G alleles of the RANTES promoter region were found to be associated with asthma/atopy in some but not all studies. Aim: The purpose of this study was to investigate the genetic influence of -403A and -28G alleles of the RANTES promoter region on the development of asthma in Lebanon. Settings and Design: This case control study was conducted at Makassed Hospital, Beirut on 40 asthmatic patients and 38 healthy controls. Methods: RANTES gene polymorphisms -403G/A and -28C/G alleles were genotyped using PCR-RFLP. Results: No significant differences in allele or genotype frequencies for the RANTES gene polymorphisms between asthmatic patients and controls were found. The difference of the -403 GA genotype frequency between patients and controls was not statisti­cally significant; (OR=0.8, 95% CI=0.2-2.3, P=0.8). Similarly, the difference of the A-allele frequencies between patients and con­trols was not significant (OR=0.824, CI=0.3-2.2, P=0.7). Conclusions: Our data show that RANTES gene promoter polymorphisms are not associated with asthma susceptibility in the Lebanese population.


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