Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
Search Ahead of print Current Issue Archives Instructions Subscribe e-Alerts Login 
Home Email this article link Print this article Bookmark this page Decrease font size Default font size Increase font size


 
Table of Contents   
POSTGRADUATE CLINICAL SECTION
Year : 2011  |  Volume : 6  |  Issue : 2  |  Page : 99-100
Hemothorax complicating rheumatoid arthritis


1 Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Date of Submission01-Aug-2010
Date of Acceptance29-Nov-2010
Date of Web Publication28-Mar-2011

Correspondence Address:
Mahesh Prakash
Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160 012
India
Login to access the Email id


DOI: 10.4103/1817-1737.78433

PMID: 21572701

Rights and Permissions



How to cite this article:
Prakash M, Ramanathan S, Singh S, Khandelwal N. Hemothorax complicating rheumatoid arthritis. Ann Thorac Med 2011;6:99-100

How to cite this URL:
Prakash M, Ramanathan S, Singh S, Khandelwal N. Hemothorax complicating rheumatoid arthritis. Ann Thorac Med [serial online] 2011 [cited 2020 Jan 25];6:99-100. Available from: http://www.thoracicmedicine.org/text.asp?2011/6/2/99/78433


A 50-year-old man presented with shortness of breath and fever for a duration of 7 days. He was a known case of rheumatoid arthritis on treatment for the past 7 years from rheumatology clinic of our institute. On clinical examination he was drowsy and hemodynamically stable. Respiratory rate was 25/min with bilateral decreased breath sounds and fine crepitations. Chest radiograph showed right-sided pleural effusion. Laboratory investigations were performed [Table 1]. Ultrasound-guided diagnostic thoracentesis showed bloody aspirate. Pleural fluid analysis revealed hematocrit, 25%; white blood cell count, 4000; protein, 3.3 g/dL; LDH, 400 U/L; and glucose, 80 mg/dL. Contrast enhanced computed tomography of chest was carried out [Figure 1] and [Figure 2].
Table 1: Laboratory study results

Click here to view
Figure 1: Computed tomography scanogram showing right pleural effusion

Click here to view
Figure 2: Computed tomography scan of chest shows right-sided hemothorax, left pleural effusion, and pericardial effusion

Click here to view



   Questions Top


  1. What are the findings on the computed tomography of the chest?
  2. What is the differential diagnosis?



   Answers Top


  1. Large right pleural effusion with hyperdense contents suggestive of hemothorax with mild left pleural and pericardial effusion was seen.
  2. Common causes of hemothorax include trauma, infections, coagulopathy, malignancy, and vascular abnormalities.



   Course of the Patient Top


The diagnosis of spontaneous hemithorax was made. Chest tube was placed which drained approximately 1 L of blood immediately and two units of whole blood transfused with close monitoring of vitals. In the next 4 h 500 ml of blood drained. The patient was conservatively managed as his hemodynamic status was stable. Pleural fluid analysis was negative for malignant cells. Abdominal fat pad biopsy turned out to be positive for amyloid (Congo red positive).


   Discussion Top


Rheumatoid arthritis is a common connective tissue disorder of autoimmune etiology affecting multiple organ systems presenting with symmetric polyarthralgia. Pleuropulmonary manifestations of RA are commonly seen in males and include pleural effusion, pneumonitis, pleuropulmonary nodules, interstitial fibrosis, arteritis, bronchiectasis, and amyloidosis. Pleural effusion is the most common chest manifestation of RA and is usually small, bilateral, and asymptomatic. It is an exudative effusion with raised LDH, increased protein, and decreased glucose. [1]

Spontaneous hemothorax is an unusual complication of RA the exact incidence of which is not known and its pathogenesis is not well understood. Hemothorax is defined as pleural fluid hematocrit >50% of blood hematocrit. Common causes of hemothorax include trauma, infections, coagulopathy, malignancy, and vascular abnormalities. [2] In our patient as coagulopathy and malignancy were ruled out, other rare cause of hemothorax, amyloidosis (secondary) was considered. A primary mechanism of bleeding in amyloidosis is coagulation abnormalities either isolated or multiple factor deficiencies. [3] But literature search revealed a few case reports of bleeding in amyloidosis secondary to amyloid infiltrate of vascular and perivascular connective tissues in the absence of coagulopathy. [4],[5] This amyloid infiltration leads to increased fragility of blood vessels leading to poor hemostasis. [4] In our case, there was significant hemothorax in the patient with long standing RA with normal coagulation tests and no other predisposing factors. Abdominal fat pad biopsy was strongly positive for amyloid and was assumed to be the cause of hemothorax. Basoglu [6] reported one case of spontaneous hemo-pneumothorax in a young patient with rheumatoid lung disease. The cause of hemopneumothorax in this patient was bleeding from the lingular branch of pulmonary artery with adjacent parenchymal necrosis.

Treatment options reported include splenectomy, aggressive treatment of the primary disease, melphalan, prednisone, tumor necrosis factor (TNF-α), and interlukins (IL-1). [3] Spontaneous remissions have also been reported. In our case hemothorax improved after chest tube drainage and the patient was clinically stable. He is now managed with disease-modifying anti-rheumatic drugs (DMARDs) and is on close follow-up.

In conclusion, hemothorax is very uncommon in a case of RA without any predisposing factors or coagulation abnormalities. One should consider the possibility of secondary amyloidosis in such long standing cases of RA.

 
   References Top

1.Helmers R, Galvin J, Hunninghake GW. Pulmonary manifestations associated with rheumatoid arthritis. Chest 1991;100:235-8.   Back to cited text no. 1
[PUBMED]  [FULLTEXT]  
2.Ali HA, Lippmann M, Mundathaje U, Khaleeq G. Spontaneous hemothorax: A comprehensive review. Chest 2008;134:1056-65.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.Sucker Cnone, Hetzel GRnone, Grabensee Bnone, Stockschlaeder Mnone, Scharf REnone. Amyloidosis and bleeding: Pathophysiology, diagnosis, and therapy.none Am J Kidney Dis 2006;47:947-55.  Back to cited text no. 3
    
4.Alwitry Anone, Brackenbury ETnone, Beggs FDnone, Soomro Inone. Vascular amyloidosis causing spontaneous mediastinal haemorrhage with haemothorax. Eur J Cardiothorac Surgnone 2001;20:871-3.  Back to cited text no. 4
    
5.Hoshino Y, Hatake K, Muroi K, Tsunoda S, Suzuki T, Miwa A, et al. Bleeding tendency caused by the deposit of Amyloid substance in the perivascular region. Intern Med 1993;32:879-81.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  
6.Basoglu A, thCelik B, thYetim TD. Massive spontaneous hemopneumothorax complicating rheumatoid lung disease. thAnn Thorac Surg 2007;83:1521-3.  Back to cited text no. 6
    


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1]



 

Top
Print this article  Email this article
 
  Search
 
  
    Similar in PUBMED
    Article in PDF (581 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Questions
    Answers
    Course of the Pa...
    Discussion
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed3204    
    Printed117    
    Emailed0    
    PDF Downloaded483    
    Comments [Add]    

Recommend this journal