Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
Search Ahead of print Current Issue Archives Instructions Subscribe e-Alerts Login 
Home Email this article link Print this article Bookmark this page Decrease font size Default font size Increase font size
ORIGINAL ARTICLE
Year : 2010  |  Volume : 5  |  Issue : 2  |  Page : 86-91

Sarcoidosis-associated pulmonary hypertension: Clinical features and outcomes in Arab patients


1 Department of Medicine, Pulmonary Division, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
2 Department of Medicine, Pulmonary Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia
3 Department of Medicine, Pulmonary Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia
4 Radiology and Medical Imaging, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
5 Family and Community Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Esam H Alhamad
Department of Medicine, Division of Pulmonary Medicine, King Khalid University Hospital, King Saud University, P.O. Box 18321, Riyadh 11415
Saudi Arabia
Login to access the Email id


DOI: 10.4103/1817-1737.62471

PMID: 20582173

Rights and Permissions

Background : Pulmonary hypertension (PH) occurs in many patients with interstitial lung disease, including sarcoidosis. We explored the frequency, clinical characteristics and outcomes of PH in Arab patients diagnosed with pulmonary sarcoidosis. Methods : A retrospective study in three tertiary hospitals was performed on 96 patients who underwent Doppler echocardiography. Demographic and clinical characteristics, physiological studies and computed tomography (CT) results were collected, and compared between patients with and without PH. Results : Twenty (20.8%) patients were found to have PH. Patients with PH were more likely to be symptomatic (cough, P = 0.008; dyspnea, P = 0.04), to have an advanced radiographic stage (P = 0.001), and to be receiving systemic therapy (P = 0.001), compared to those without PH. Physiological data including pulmonary function test parameters, arterial blood gas levels and oxygen saturation at rest and after exercise were all significantly lower in patients with PH compared to those without PH. Comparison of CT patterns between patients with and without PH showed significant differences in the frequencies of ground-glass opacity (61.5 vs. 28.8%, P = 0.032) and fibrosis (76.9 vs. 44.2%, P = 0.035). In total, four patients died during the study period, including three with evidence of PH. Conclusions : The frequency of PH in the present study was 20.8%. Clinical, physiologic and radiographic characteristics appeared to differentiate patients with PH from those without PH. The presence of PH contributed to poor outcomes in patients with pulmonary sarcoidosis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3870    
    Printed175    
    Emailed1    
    PDF Downloaded553    
    Comments [Add]    
    Cited by others 10    

Recommend this journal